silvadene cream for burns

Apply the cream to cover the whole area evenly. Silvadene cream (silver sulfadiazine) is a prescription treatment that is applied to skin wounds and serious burns. This medicine should also not be used on premature babies or any child younger than 2 months old. Silvadene cream 1%. However, this medicine can cause serious medical problems in a newborn and should not be used during late pregnancy. Discuss the risks and benefits with your doctor. US residents can call their local poison control center at 1-800-222-1222. Do not share this medication with others. Cream 1% (silver sulfadiazine) with the eye. It can also prevent infection. Silver sulfadiazine cream is a type of antibiotic medication that treats second- and third-degree burns. WebMD does not provide medical advice, diagnosis or treatment. Silver sulfadiazine works by stopping the growth of bacteria that may infect an open wound. Some of the reactions, which have been associated with Generic name: silver sulfadiazine topical [SIL-ver-SUL-fa-DYE-a-zeen-TOP-ik-al] There have not been very many reliable studies about using Silvadene cream during pregnancy, but you should tell your provider if you're pregnant. This product may contain inactive ingredients, which can cause allergic reactions or other problems. It is unknown if this medication passes into breast milk. possibility should be noted that silver may inactivate such enzymes. Brand names: Silvadene, SSD, Thermazene The prescription can be filled in any drug store. Do not use if cream has darkened in color. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Burn patients who meet American Burn Association referral criteria should be promptly transferred to a burn center. The drug should not be withdrawn from the therapeutic regimen An overdose of Silvadene is not expected to be dangerous. This medicine can make you more sensitive to the sun. Dressings may be applied over the cream, but only if needed. Burn prevention research demonstrated that a five-minute educational video shown to first-time parents and to adults 50 years and older significantly increased their home fire safety knowledge. Renal function should be carefully monitored and the Prompt institution of appropriate regimens for care of the burned patient is of prime importance and Khorasani G, Hosseinimehr SJ, Azadbakht M, Zamani A, Mahdavi MR. Aloe versus silver sulfadiazine creams for second-degree burns: a randomized controlled study. Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. The burn areas should be covered with SILVADENE Cream 1% at all times. 1996-2023 RxList, Inc. An Internet Brands company. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication. Silvadene Cream may interact with cimetidine. of the tissue damage. (See CONTRAINDICATIONS.). Rebound to normal leukocyte levels follows onset within 2 to 3 days. Int J Burns Trauma. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. RxList does not provide medical advice, diagnosis or treatment. Some items may interact with your medicine. RxList does not provide medical advice, diagnosis or treatment. SILVADENE Cream 1% (silver sulfadiazine) is contraindicated in patients who are hypersensitive to Follow the instructions on the label to safely apply this medication to your skin as directed. Your health care professional will clean and remove the dead tissue from the wound to help the healing process. If allergic Throw away any unused medicine after the expiration date. They need to know if you have any of these conditions: glucose-6-phosphate dehydrogenase (G6PD) deficiency, an unusual or allergic reaction to silver sulfadiazine, sulfa drugs, other medicines, foods, dyes, or preservatives. J Med Life. It is used on the skin for second or third degree burns. influenced by continuation of silver sulfadiazine therapy. Although the rule of nines allows for a faster assessment, Lund and Browder charts provide a more accurate estimation in children and adults, with surface area adjusted to age.1,3,9 An illustration of these methods is available at https://www.aafp.org/afp/2012/0101/p25.html#afp20120101p25-f1. severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling. Treatment is normally continued until the site is ready for grafting or . Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Injuries to the face and neck and exposure to fire in an enclosed space or to chemicals predispose patients to airway injury and warrant close monitoring for airway compromise.14 A rapid history directed at identifying the causative agent and determining the depth and extent of the burn is important. Skin is the largest organ of the body and functions include thermoregulatory control, prevention of fluid loss, vitamin D synthesis, sensory contact with the environment, and a physical barrier against injury.4 The outermost skin layer is the avascular epidermis, which is 10 to 100 cells thick.5 Under the epidermis and basal membrane is the dermis, which contains sebaceous and sweat glands, hair follicles, blood vessels, nerves, and stem cells.1,5 The dermis lies on the subcutis, which consists of thick adipose tissue.5, The American Burn Association classifies burns by depth: superficial (first-degree), partial-thickness (second-degree), and full-thickness (third-degree). Silvadene Cream is available in generic form. COMMON BRAND NAME (S): Silvadene, SSD, SSD AF . . Author disclosure: No relevant financial affiliations. infants during the first 2 months of life. Munteanu A, Florescu IP, Nitescu C. A modern method of treatment: The role of silver dressings in promoting healing and preventing pathological scarring in patients with burn wounds. Cleveland Clinic is a non-profit academic medical center. Persistent lactic acidosis after chronic topical application of silver sulfadiazine in a pediatric burn patient: A review of the literature. Surg Today. Consult your doctor for more details. FREE delivery silver nitrate and sodium sulfadiazine. Copyright 2023 American Academy of Family Physicians. Used to prevent and treat wound sepsis on patients with second and third degree burns. The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U.S. Army Medical Department or the U.S. Army at large. Do not get this medicine in your eyes. Silvadene can have side effects. sulfonamides, a decision should be made whether to discontinue nursing or to discontinue the drug, In Canada - Call your doctor for medical advice about side effects. Talk to your pharmacist for more details. Superficial partial-thickness burns are exudative, blanch with pressure, may blister, and are generally painful.1,3 Most will heal within three weeks.1,6 Deep partial-thickness burns involve the reticular dermis, are drier, and do not blanch.3 These usually take more than three weeks to heal and lead to loss of the dermal layer and scarring.3,6 Deep partial-thickness burns should receive immediate evaluation by a burn surgeon for consideration of early operative management with tangential excision and skin grafting.3,6 Full-thickness burns (Figure 37) extend through the entire dermis and into underlying fat and connective tissue and require automatic referral to a burn center.1,3,5 These burns appear white, waxy, dry, and leathery. All rights reserved. A common prescription cream to treat second-degree burns is silver sulfadiazine (Silvadene). Before using silver sulfadiazine, tell your doctor or pharmacist if you are allergic to it; or to other sulfa antibiotics (such as sulfamethoxazole); or if you have any other allergies. In considering the use of topical proteolytic enzymes in conjunction with SILVADENE Cream 1%, the If Silvadene gets in your eyes, nose, or mouth, rinse with water. Dai T, Huang YY, Sharma SK, Hashmi JT, Kurup DB, Hamblin MR. Topical antimicrobials for burn wound infections. Absorption of silver sulfadiazine varies depending upon the percent of body surface area and the extent Silvadene also helps prevent the growth of bacteria and yeasts like Candida albicans. Use this medication regularly to get the most benefit from it. If you miss a dose, use it as soon as you can. Advertising on our site helps support our mission. There is potential cross-sensitivity between silver sulfadiazine and other sulfonamides. Finish the full course of medicine prescribed by your doctor or health care professional even if you think your condition is better. However, similar drugs pass into breast milk and may harm nursing infants who are ill, premature, less than 2 months old, or who have certain disorders (such as jaundice, high blood levels of bilirubin, G6PD deficiency). Jenny Lelwica Buttaccio, OTR/L, is a licensed occupational therapist and advocate for patients with Lyme disease. Your symptoms may improve before the infection is completely cleared. Superficial partial-thickness burns extend into the dermis, may take up to three weeks to heal, and require advanced dressings to protect the wound and promote a moist environment. Absorption of the propylene glycol vehicle has been When you visit the site, Dotdash Meredith and its partners may store or retrieve information on your browser, mostly in the form of cookies. bacteria as well as being effective against yeast. From 2011 to 2015, almost one-fourth of all burns occurred in children younger than 15 years.42 In 2015, unintentional fire and burn injuries were the third leading cause of injury-related deaths among U.S. children three to nine years of age and the eighth leading cause of all deaths among adults 65 years and older.2,10,42 Sunburns are the most common and preventable type of burns in children, affecting up to 50% of children before 11 years of age.3 Table 4 lists common sunburn prevention strategies.43,44 Scalds are the most common type of burns in children five years or younger and are often a result of spilling hot liquids during cooking.10 Bathing-related scalds are most common with sink bathing when a child may inadvertently turn on the hot water or the temperature of running water may fluctuate.45 Table 5 lists childhood burn prevention strategies.46,47, Older adults are at increased risk of burn injuries because of thinning skin, cognitive decline, decreased sensation, and comorbid medical conditions.48 Frailty in older patients predicts morbidity and mortality from burns.49 Although they are among the fastest growing population in the United States, adults 60 years and older are the least likely to be targeted for burn prevention.50 Table 6 lists key strategies for burn prevention for older adults.51. resistant to other antimicrobial agents and that the compound is superior to sulfadiazine. This is not a complete list of side effects and others may occur. NOTE: This sheet is a summary. To ensure that the medication is sterile, the Canadian 250- and 500-gram jars should be discarded 24 hours after opening. Consult your doctor before breast-feeding. This medicine should also not be used on premature babies or any child younger than 2 months old. Do not use double or extra doses. Recent Pat Antiinfect Drug Discov. Silvadene Cream 1% (silver sulfadiazine) is a topical (for the skin) antibiotic used to treat or prevent infections on areas of burned skin. studies in pregnant women. Silvadene may cause serious medical problems in a newborn if you use Silvadene during late pregnancy (close to your delivery date). Burn injuries are more likely to occur in children and older people. Store at Controlled Room Temperature 20 to 25C (68 to 77F). Silver sulfadiazine has been shown to delay wound healing by impairing leukocytes and epidermal growth, which can increase scar formation.30 Additionally, a Cochrane review suggests an association between silver sulfadiazine and increased burn wound infection rates.31 Table 2 lists topical agents commonly used in the treatment of burns.18,30,32,33, With the second method, advanced dressings of various materials are applied to the wound and kept in place for up to 14 days, depending on manufacturer specifications.13,29 Advanced dressings have inherent antimicrobial properties, keep injured tissue moist, and control exudative fluids. Road Rash: Symptoms, Diagnosis, Causes, and Treatment, Blisters on Toes: Causes and What to Do About Them, Topical antimicrobials for burn wound infections, Silver: an age-old treatment modality in modern times, Persistent lactic acidosis after chronic topical application of silver sulfadiazine in a pediatric burn patient: A review of the literature, A modern method of treatment: The role of silver dressings in promoting healing and preventing pathological scarring in patients with burn wounds, Aloe versus silver sulfadiazine creams for second-degree burns: a randomized controlled study. Silver Sulfadiazine Cream. For people with very bad wounds or burns, Silvadene can help stop infections from spreading to the surrounding skin or getting into the bloodstream where it could cause a life-threatening condition called sepsis. https://www.aafp.org/afp/2012/0101/p25.html#afp20120101p25-f1, Burns to the face, hands, feet, major joints, genitalia, or perineum, Children in health care facilities without staff trained to treat children or appropriate equipment for children, Full-thickness (third-degree) burns at any age, Greater than 10% total body surface area involved, Need for special support (social, emotional, rehabilitative), Preexisting medical issues that may complicate treatment or recovery or increase mortality risk, Inexpensive, painless, can be used on the face and near mucous membranes, Narrow microbial coverage, need for frequent dressing changes, does not penetrate eschar, may cause urticaria or burning, Impregnated nonadherent gauze (Xeroform, Vaseline gauze), Nonadherent barrier, secondary dressing over absorptive dressing, helps maintain moist environment, clings to the body, Water-based cream; bacteriostatic against gram-positive and gram-negative bacteria, Pseudomonal coverage, penetrates eschar, used for deep burns or exposed cartilage, can be used on the face, Pain associated with application, may delay wound healing, associated with metabolic acidosis, Variety of preparations, including topical and honey-based hydrogel-impregnated dressings, Inhibits growth of common burn pathogens, reduces healing time for partial-thickness burns compared with simple dressings, Ointment; inhibits bacterial protein and RNA synthesis, bactericidal at high concentrations, Good gram-positive antimicrobial coverage, active against most strains of methicillin-resistant, Need for frequent dressing changes, expensive, Water-based cream; interferes with bacterial DNA synthesis, Painless, long shelf life, broad antimicrobial coverage, Need for frequent dressing changes; delays wound healing; associated leukopenia; stains tissues; contraindicated in pregnant women, nursing mothers, newborns, and those with a sulfa allergy, Hydrophilic absorptive dressing with a viral and bacterial barrier; facilitates autolytic debridement, Can remain in place for up to seven days, good for management of light to moderate exuding wounds while keeping wound moist, shorter time to wound closure than silver sulfadiazine (Silvadene), assists in scar management, inexpensive, Cannot be used for large exuding wounds, malodorous, Nonabsorptive, transparent, open mesh, polyamide net coated with a soft silicone layer, Can remain in place for up to 14 days, conforms to the shape of the wound, allows for drainage of exudate to secondary bandage, Layered nanocrystalline silver-coated mesh surrounding an inner rayon layer, Three-day and seven-day versions, broad antimicrobial coverage, Cannot be used with magnetic resonance imaging, may not completely clear wound of bacteria, some pain with initial application, temporary skin staining, may dry out and adhere (moistened secondary dressing should be used for optimal moisture level), cannot be used with oil-based products, Absorptive carboxy-methylcellulose sodium fiber dressing, Can remain in place for up to seven days, requires fewer dressing changes than with other silver-based dressings, painless, nonadhering, broad antimicrobial spectrum, facilitates debridement, Cannot be used with oil-based products, amount of exudate dictates frequency of changes, Can remain in place for up to seven days, decreases pain, antimicrobial, maintains moist environment, Expensive, cannot be used with magnetic resonance imaging, cannot be used with hypochlorite solutions or hydrogen peroxide, Avoid outdoor activities during peak sun intensity (10 a.m. to 4 p.m.), even on cloudy days, Wear protective clothing (e.g., long sleeves, long pants, wide-brim hats) during the day, For patients at increased risk, consider clothing with a high UV protection factor (> 30), Use sunglasses that provide 100% UVA and UVB protection, Use a broad-spectrum sunscreen with an SPF of at least 15, Use a sunscreen that is water-resistant (40 to 80 minutes of protection in the water), Apply sunscreen to dry skin 15 to 30 minutes before exposure to the sun, Reapply sunscreen every two hours or earlier when sweating, swimming, or towel-drying, Discard any sunscreen older than three years, Avoid using tablecloths and place mats because a child could pull them, causing spills, Block access to high-risk areas, such as kitchens and bathrooms, with gates or child locks, Consider using antiscalding devices or thermometers, Do not heat formula in a bottle, and never microwave a bottle, Do not hold a child and a hot beverage at the same time, Do not run water while a child is being bathed, do not bathe a child in a sink; children's baths should be supervised, Keep all chairs away from counters and the stove, Keep all chemicals, matches, and lighters locked up or out of reach of children, Set water heater to 120F (48.9C) or lower; for small children, keep water temperature below 101F (38.3C), Test all foods and liquids that are microwaved before giving to children. In some cases, the drug may build up in the body and reach unsafe levels. JASON S. LANHAM, MD, MA, NICOLE K. NELSON, DO, BRYAN HENDREN, MD, AND TENEISHA S. JORDAN, MD. It works by killing the bacteria or preventing its growth. Covering it will also reduce infection risks. Prescription silver sulfadiazine cream (1 jar (50g) 1%) edit. 2013;3(1):1-8. (See CONTRAINDICATIONS.). An increased incidence of leukopenia has Patient information: See related handout on burn injuries, written by the authors of this article. Data Sources: PubMed, Essential Evidence Plus, the Cochrane database, and Ovid were searched using the key terms burn management, burn prevention, burn prevalence, outpatient burns, topical burn treatment, sunburn, sunburn management, partial thickness burns, diabetics burns, burn dressings, and water burn treatment. Depth can also increase because of inadequate treatment or superinfection.15, For all types of minor burn injuries, the goals of initial treatment are to minimize the extent of the burn, clean the wound, and address pain.13,14 For scalds, immediate clothing removal lessens burn injury.16 For chemical burns, all clothing is assumed to be contaminated and should be removed using appropriate protective equipment, such as eye protection and gloves.17 It is important to ensure the removal of all items that can cause a tourniquet effect when a body part swells, such as jewelry, belts, watches, and diapers.14,18 Because patients with burns have impaired thermoregulation, the environment should be kept warm during examination.14,18, Active cooling of the burn surface with running tap water (at 46.4F [8C] to 77F [25C]) for at least 20 minutes has been shown to reduce burn depth, improve healing time, and decrease grafting requirements.14,16,19,20 Cooling should commence within 30 minutes of the initial burn, but emerging evidence suggests this benefit may be achieved up to three hours after the burn.19 Wet dressings are not effective at cooling wounds.14 Ice should not be used because of its vasoconstrictive effects and risk of further tissue injury.14 Contaminants and nonadherent necrotic skin should be removed with gentle irrigation to prevent infection.13,18 Irrigation with tap water instead of sterile or antiseptic agents does not increase infection rates.13,2123, Superficial burns do not require dressings to promote healing; however, covering burns with wet gauze may reduce pain.18,24 Aloe vera cream and nonsteroidal anti-inflammatory drugs may also assist with pain control.18,25,26 Superficial partial-thickness burns require a moist, protected environment to promote reepithelialization while preventing desiccation, burn progression, and secondary infection.1, Blistering mostly occurs with superficial partial-thickness burns, and management is controversial.15,18 Characteristics that favor debridement include size greater than 6 mm, location over joints, and high likelihood of spontaneous rupture.13,18 Debridement reduces pressure on the wound; removes necrotic skin, which may act as a nidus of infection; allows visualization of the wound bed; and permits placement of an antibacterial dressing directly over intact skin.15,27 Recent evidence suggests that deroofing blisters is not superior to aspiration in regard to pain reduction and wound healing.28, Two methods of dressing partial-thickness wounds are commonly practiced. You should also tell your provider if you're breastfeeding. a skin ulcer. Treatment usually continues until the wound is completely healed or until the site is ready for skin grafting. This medicine is for use on the skin only. It is unknown if this medication passes into breast milk. INDICATIONS AND USAGE. Silvadene is for use only on the skin. 4 Despite SSD's popularity, compelling evidence to support its use in t. Silver sulfadiazine is an antibiotic. The American Burn Association has published criteria for burn center referral. 1. Some are only mild while others can be serious and may mean that you cannot use the cream. revealed no evidence of carcinogenicity. The burn areas should be covered with SILVADENE Cream 1% at all times. Although few have been reported, it is possible that any adverse reaction therapy.1,2,3 Leukopenia associated with silver sulfadiazine administration is primarily characterized by burning sensation, rashes, and interstitial nephritis. Breast-feeding while using this drug is not recommended in infants with these conditions. to produce its bactericidal effect. separation, in some cases necessitating escharotomy in order to prevent contracture. 18, 24 Aloe vera cream and nonsteroidal anti-inflammatory drugs may also . This medication is for use on the skin only. 2016;9(3):306-315. The person applying silver sulfadiazine to burn wounds should wear sterile disposable gloves. Because sulfonamide therapy is known to increase the possibility of kernicterus, SILVADENE Cream 131-20) , 25 g (NDC 61570-131-25), 50 g (NDC 61570-131-55) and 85 g (NDC 61570-131-85). Last reviewed on RxList: 5/23/2022 All rights reserved. Today, silver-infused wound dressings and other products are popular because they have strong and broad infection-fighting qualities. women approaching or at term. Treatment with SILVADENE Cream 1% should be continued until satisfactory healing has occurred, or Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. If needed, apply more cream to replace any medicine that has come off on bandages, clothing, or bed linens. However, if individual patient requirements make In the US - Call your doctor for medical advice about side effects. Consult your doctor before breast-feeding. Mayo Clinic does not endorse companies or products. The burn wounds are then cleansed and debrided, and SILVADENE Cream 1% (silver sulfadiazine) is applied under sterile conditions. The cream should be applied once to twice daily to a thickness of approximately 1/16 inch. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Read the Patient Information Leaflet if available from your pharmacist before you start using silver sulfadiazine and each time you get a refill. 3. It fights bacteria and yeast on the skin. Silvadene Cream combines the beneficial properties and potential adverse systemic reactions of silver nitrate and sulfonamides. It is bactericidal for many gram-negative and grampositive Cover the wound with gauze or a bandageespecially if you want to safeguard the burn from knocks and bumps. responses between the elderly and younger patients, but greater sensitivity of some older individuals Things to remember when you fill your prescription. I have noticed increased popularity in the use of silver sulfadiazine cream (Silvadene) for a variety of wounds, including pressure sores and similar wounds, but not third-degree burns. Data sources include IBM Watson Micromedex (updated 14 May 2023), Cerner Multum (updated 28 May 2023), ASHP (updated 10 Apr 2023) and others. thickness to full thickness by sepsis. discoloration (brown/gray/blue) of skin and mucous membranes (such as the gums). Number of Sensitive Strains /Total Number of Strains Tested. All Rights Reserved. You and your healthcare provider will need to weigh the risks and benefits of using Silvadene. 14-day supply +more With insurance est. They may advise against using it, especially if you are close to your due date. It is used on the skin for second or third degree burns. This survey is being conducted by the WebMD marketing sciences department. Silvadene (for the skin) is used to treat or prevent serious infection on areas of skin with second- or third-degree burns. the therapeutic benefit being achieved. In the treatment of burn wounds involving extensive areas of the body, the serum sulfa concentrations may approach adult therapeutic levels (8 mg% to 12 mg%). It also provides a moist environment while the burn heals. Compare prices and print coupons for Silvadene (Silver Sulfadiazine) and other drugs at CVS, Walgreens, and other pharmacies. Silver sulfadiazine has broad antimicrobial activity. All burn injuries are considered trauma, prompting immediate evaluation for concomitant injuries. Drug interactions may change how your medications work or increase your risk for serious side effects. Several cases of transient leukopenia have been reported in patients receiving silver sulfadiazine Whenever necessary, the cream should be reapplied to . Fabric (such as clothing, bedding, dressings) that has been in contact with this medication burns more easily and may be a fire hazard. You can get generic silver sulfadiazine products at the pharmacy, but over-the-counter products are not as strong as Silvadene. What Are Side Effects of Silvadene? Other infrequently occurring events include skin necrosis, erythema multiforme, skin discoloration, The wound should be covered with the cream at all times. 2010;5(2):124-51. doi:10.2174/157489110791233522. Dressings usually are not required, but may be used. Review/update the They may prescribe antibiotics to clear the infection from your body. FDA pregnancy category B. Silvadene is not expected to harm an unborn baby. Silver sulfadiazine acts only on the cell membrane and cell wall Casey Gallagher, MD, is board-certified in dermatology. Available for Android and iOS devices. Silvadene is only available by prescription. You may report side effects to FDA at 1-800-FDA-1088. Silvadene may cause serious medical problems in a newborn if you use this medicine during late pregnancy (close to your delivery date). The cream should be applied once to twice daily to a thickness of approximately 1/16 inch. life-threatening cutaneous reactions [Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis Formulated as a 1% topical cream, SSD is FDA-approved as an adjunct for the prevention and treatment of wound sepsis in patients with second- and third-degree burns. Burn patients with diabetes who develop complications, such as cellulitis, should be referred to a burn center for further treatment.